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Product Information:

TLR4-IN-2

TLR4-IN-2 (Compound Racemic-11k) is inhibitors of TLR4, JNK, and NF-κB. TLR4-IN-2 inhibits NO production in LPS-stimulated RAW264.7 cells with an IC50 value of 23.2 µM. TLR4-IN-2 exerts anti-inflammatory activity by inhibiting TLR4 expression, reducing JNK phosphorylation, thereby suppressing the activation of NF-κB, blocking the transcription of inflammation-related genes, reducing the expression of iNOS and COX-2, and decreasing the production of inflammatory mediators such as NO, PGE 2, and TNF-α. TLR4-IN-2 is promising for research of inflammatory diseases, such as rheumatoid arthritis and various inflammatory disorders .

Cat. No.: EX-A15969    Purity: >98%
Chemical
Chemical structure of TLR4-IN-2


For research only, Do not use for Human!

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SynonymsNitric oxide production-IN-2
CAS No.1019984-44-1
Purity>98%
FormulaC23H20O3
Mol Weight344.4031
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Tang ML, et al. Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents. Eur J Med Chem. 2016 May 4;113:63-74.

CoACoA of TLR4-IN-2
Smiles:O=C1C2=CC=C(OC)C=C2C(C=3C=CC=CC3)C1C4=CC=C(OC)C=C4

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