THK-5107

THK-5117, an arylquinoline derivative, displays high binding affinity to tau fibrils with a Ki of 10.5 nM. THK-5117 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD) brain homogenates. 18F-THK-5117 has the potential to act as a tau imaging PET probe .


Cat. No.: EX-A6644A	Purity: >98%

	Chemical structure of THK-5107

For research only, Do not use for Human!

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CAS No.	1374107-54-6
Purity	>98%
Formula	C19H19FN2O2
Mol Weight	326.3648
Color	Off-white to light yellow
State	solid powder
Shelf Life	>1 years if stored properly
Storage	4°C, sealed storage, away from moisture and light
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Nobuyuki Okamura, et al. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med. 2013 Aug;54(8):1420-7.
CoA	CoA of THK-5107

Smiles:	OC(COC1=CC=C2N=C(C3=CC=C(NC)C=C3)C=CC2=C1)CF


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