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Product Information:

Thalidomide-5-NH-PEG3-NH2 hydrochloride

Thalidomide-5-NH-PEG3-NH2 hydrochloride is a Thalidomide -based cereblon ligand that recruits CRBN proteins. Thalidomide-5-NH-PEG3-NH2 hydrochloride can be connected to the target protein ligand through a linker to form a PROTAC molecule. For example, THAL-SNS-032.

Cat. No.: EX-A10498    Purity: >98%
Chemical
Chemical structure of Thalidomide-5-NH-PEG3-NH2 hydrochloride


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1g1050In-stock
5gget quoteIn-stock


CAS No.2863635-01-0
Purity>98%
FormulaC21H29ClN4O7
Mol Weight484.931
ColorLight yellow to yellow
StateSolid
Shelf Life>3 years if stored properly
StoragePowder -20°C, sealed storage, away from moisture and light; In solvent -20℃, 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief]

CoACoA of Thalidomide-5-NH-PEG3-NH2 hydrochloride
Smiles:O=C1NC(C(CC1)N2C(C3=CC=C(NCCOCCOCCOCCN)C=C3C2=O)=O)=O.Cl

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