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Product Information:

TH-302

Evofosfamide (TH-302) is a hypoxia-activated proagent with IC50 of 10 μM and 1000 μM in hypoxia (N2) and normoxia (21% O2), respectively.

Cat. No.: EX-A1740    Purity: >98%
Chemical
Chemical structure of TH-302


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg472in_stock
500mg875in_stock
1g1260in_stock
2g2061in_stock
5g4096in_stock


SynonymsEvofosfamide
CAS No.918633-87-1
Purity>98%
FormulaC9H16Br2N5O4P
Mol Weight449.036
Statesolid powder
SolubilitySoluble in DMSO/water
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Meng F, et al. Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition. BMC Cancer. 2015 May 21;15:422.

[2]. Zhang X, et al. MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts. PLoS One. 2016 May 26;11(5):e0155289.

[3]. Peeters SG, et al. TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging. Clin Cancer Res. 2015 Jul 1;21(13):2984-92.

CoACoA of TH-302
Smiles:CN1C(COP(=O)(NCCBr)NCCBr)=CN=C1[N+]([O-])=O

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