TH-257

TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM. TH263 (EX-A4475A) as negative control for TH-257.


Cat. No.: EX-A4475	Purity: >98%

	Chemical structure of TH-257

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	685	In-stock
500mg	885	In-stock
1g	1285	In-stock
5g	3450	In-stock
10g	5650	In-stock

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Synonyms	TH 257
CAS No.	2244678-29-1
Purity	>98%
Formula	C24H26N2O3S
Mol Weight	422.54
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Manetti F. Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trials. Eur J Med Chem. 2018 Jul 15;155:445-458. [2]. Collins R, et, al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65(20):13705-13713.
CoA	CoA of TH-257

Smiles:	CCCCN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3


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