Tenapanor dihydrochloride

Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia.


Cat. No.: EX-A2506A	Purity: >98%

	Chemical structure of Tenapanor dihydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	450	In-stock
250mg	785	In-stock
500mg	1185	In-stock
1g	1685	In-stock
5g	4450	In-stock
10g	get quote	In-stock

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Synonyms	AZD1722 dihydrochloride
Synonyms 2	RDX5791 dihydrochloride
CAS No.	1234365-97-9
Purity	>98%
Formula	C50H68Cl6N8O10S2
Mol Weight	1217.971
Color	white to off-white
State	solid powder
Solubility	Soluble in DMSO/H2O
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, away from moisture and light, 2 year; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Can be arranged to be shipped with ice bag upon request.

Reference:	[1]. King AJ, et al. Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. Sci Transl Med. 2018 Aug 29;10(456):eaam6474. [2]. King AJ, et al. Combination treatment with tenapanor and sevelamer synergistically reduces urinary phosphorus excretion in rats. Am J Physiol Renal Physiol. 2021 Jan 1;320(1):F133-F144.
CoA	CoA of Tenapanor dihydrochloride

Smiles:	Cl.Cl.CN1C[C@@H](C2=CC(=CC=C2)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)C2=CC=CC(=C2)[C@@H]2CN(C)CC3=C2C=C(Cl)C=C3Cl)C2=C(C1)C(Cl)=CC(Cl)=C2


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