Teglarinad chloride

Teglarinad chloride (GMX1777) is a proagent of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis[1][2].


Cat. No.: EX-A15442	Purity: >98%

	Chemical structure of Teglarinad chloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	928	in-stock
50mg	1448	in-stock
100mg	2250	in-stock
500mg	get quote	in-stock

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Synonyms	GMX1777
Synonyms 2	EB-1627
CAS No.	432037-57-5
Purity	>98%
Formula	C30H43Cl2N5O8
Mol Weight	672.597
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture, 2 year; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kato H, et, al. Efficacy of combining GMX1777 with radiation therapy for human head and neck carcinoma. Clin Cancer Res. 2010 Feb 1;16(3):898-911. [2]. Beauparlant P, et, al. Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777. Anticancer Drugs. 2009 Jun;20(5):346-54.
CoA	CoA of Teglarinad chloride

Smiles:	COCCOCCOCCOCCOC(=O)OC[N+]1=CC=C(C=C1)NC(=NCCCCCCOC2=CC=C(C=C2)Cl)NC#N.[Cl-]


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