TDP-43 degrader-1

TDP-43 degrader-1 (Compound example 7) is a TDP-43 degrader. TDP-43 degrader-1 reduces the aggregation of TDP-43-positive HuR stress granules in cells and promotes the relocalization of abnormally distributed TDP-43 in the cytoplasm to the nucleus. TDP-43 degrader-1 can be used in the study of amyotrophic lateral sclerosis and Alzheimer's disease.


Cat. No.: EX-A12869	Purity: >98%

	Chemical structure of TDP-43 degrader-1

For research only, Do not use for Human!

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CAS No.	2902692-25-3
Purity	>98%
Formula	C28H29N3O3
Mol Weight	455.5482
Color	White to off-white
State	Solid
Solubility	DMSO : 16.67 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Solas Dennis, et al. Preparation of substituted isoquinolines for the treatment of ALS. United States, US20230037538 A1 2023-02-09
CoA	CoA of TDP-43 degrader-1

Smiles:	CN1C(C(C(/C=C/C2C3=CC(OC)=C(OCC4=CC=CC=C4)C=C3CCN2)=C1)=C5)=NC=C5OC


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