TD-428

TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 linked to JQ1. TD-428 efficiently induce BET protein degradation.


Cat. No.: EX-A4795	Purity: 98+%

	Chemical structure of TD-428

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
1g	4800	7-8 weeks
5g	get quote	Inquire

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CAS No.	2334525-50-5
Purity	98+%
Formula	C43H43ClN10O7S
Mol Weight	879.382
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kim SA, et al. A novel cereblon modulator for targeted protein degradation. Eur J Med Chem. 2019 Mar 15;166:65-74.
CoA	CoA of TD-428

Smiles:	O=C(NC1=CC(OCCOCCOCCNC2=C3C(N=NN(C(CC4)C(NC4=O)=O)C3=O)=CC=C2)=CC=C1)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5


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