background


Product Information:

TCN 201

TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor.

Cat. No.: EX-A4411    Purity: >98%
Chemical
Chemical structure of TCN 201


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
1g625In-stock
5g1185In-stock
10g1885In-stock
25g2985In-stock
100gget quoteIn-stock


SynonymsTCN-201
CAS No.852918-02-6
Purity>98%
FormulaC21H17ClFN3O4S
Mol Weight461.894
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Bettini E, et, al. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J Pharmacol Exp Ther. 2010 Dec; 335(3): 636-44.

[2]. Edman S, et, al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep; 63(3): 441-9.

[3]. Bu F, et, al. NR2A contributes to genesis and propagation of cortical spreading depression in rats. Sci Rep. 2016 Mar 22;6:23576.

[4]. Shatillo A, et, al. Involvement of NMDA receptor subtypes in cortical spreading depression in rats assessed by fMRI. Neuropharmacology. 2015 Jun; 93:164-70.

CoACoA of TCN 201
Smiles:O=C(NNC(C1=CC=CC=C1)=O)C2=CC=C(CNS(=O)(C3=CC=C(F)C(Cl)=C3)=O)C=C2

KEYWORDS: buy TCN 201 | TCN 201 supplier | purchase | cost | manufacturer | order | distributor | buy 852918-02-6 | 852918-02-6 supplier