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Product Information:

TC-S 7009

TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ≫ 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression.

Cat. No.: EX-A7582    Purity: >98%
Chemical
Chemical structure of TC-S 7009


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg685In-stock
250mg900In-stock
500mg1385In-stock
1g1885In-stock


CAS No.1422955-31-4
Purity>98%
FormulaC12H6ClFN4O3
Mol Weight308.652
ColorLight yellow to yellow
Statesolid powder
SolubilityDMSO : 50 mg/mL
Shelf Life>2 years if stored properly
StoragePowder   -20°C, 3 years , 4°C, 2 years ; In solvent  -20°C, 1 month
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Scheuermann TH, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013 Apr;9(4):271-6.

[2]. Senavirathna LK, et al. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep. 2018 Feb 9;8(1):2709.

CoACoA of TC-S 7009

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