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Product Information:

TC-E 5008

TC-E 5008 is a potent mutant IDH1 inhibitor with Ki values of 190 nM and 120 nM for R132H and R132C IDH1 mutants, respectively. TC-E 5008 exhibits very weak activity against WT-IDH1 with a Ki value of 12.3 μM. TC-E 5008 has anti-proliferative activity on multiple ER positive breast cancer cell lines[1][2].

Cat. No.: EX-A14636    Purity: >98%
Chemical
Chemical structure of TC-E 5008


For research only, Do not use for Human!

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CAS No.50405-58-8
Purity>98%
FormulaC13H13NO2
Mol Weight215.2478
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Baisong Zheng, et al. Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. ACS Med Chem Lett. 2013 Jun 13;4(6):542-546.

[2]. Vasanth S. Murali, et al. Cancer drug discovery as a low rank tensor completion problem. bioRxiv, March 9, 2021.

CoACoA of TC-E 5008
Smiles:CC1=CC(=O)N(C(=C1)CC2=CC=CC=C2)O

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