TBAJ-587

TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 μg/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibition of the cardiac potassium channel protein coded by the hERG, which is important for cardiac repolarization.


Cat. No.: EX-A1526	Purity: >98%

	Chemical structure of TBAJ-587

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	1900	In-stock
1g	2800	In-stock
2g	get quote	In-stock
3g	get quote	In-stock
5g	get quote	In-stock

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CAS No.	2252316-16-6
Purity	>98%
Formula	C30H33BrFN3O5
Mol Weight	614.503
Color	white to off-white
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sutherland HS, et al. 3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel. Bioorg Med Chem. 2019 Apr 1;27(7):1292-1307.
CoA	CoA of TBAJ-587

Smiles:	COC1=C(F)C([C@H](C2=CC3=CC(Br)=CC=C3N=C2OC)[C@](O)(C4=CC(OC)=NC(OC)=C4)CCN(C)C)=CC=C1


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