TAT-EE3

TAT-EE3 is a neuroprotective peptide which can uncouple TRPM2-NMDARs interaction. TAT-EE3 inhibits TRPM2-induced enhancement of NMDAR surface expression and current amplitude.TAT-EE3 protects neurons against ischemic injury in vitro and in vivo. TAT-EE3can be used for the study of ischemic stroke .


Cat. No.: EX-A17208	Purity: >98%

	Chemical structure of TAT-EE3

For research only, Do not use for Human!

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CAS No.	2899218-49-4
Purity	>98%
Formula	C135H228N48O49S
Mol Weight	3339.612
Color	White to off-white
State	Solid
Solubility	soluble in H2O
Shelf Life	>2 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zong P, et al. Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury. Neuron. 2022 Jun 15;110(12):1944-1958.e8.
CoA	CoA of TAT-EE3

Smiles:	[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O)C)=O)CC(C)C)=O)CCSC)=O)CCC(O)=O)=O)CCC(O)=O)=O)CO


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