TASIN-1 Hydrochloride

TASIN-1 Hydrochloride is a novel truncated APC selective inhibitor, selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signalling in colon cancer cells.


Cat. No.: EX-A9410	Purity: >98%

	Chemical structure of TASIN-1 Hydrochloride

For research only, Do not use for Human!

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CAS No.	792927-06-1
Purity	>98%
Formula	C18H29ClN2O3S
Mol Weight	388.952
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhang L, Kim SB, Luitel K, Shay JW. Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells. Mol Cancer Ther. 2018 Feb 21. pii: molcanther.0887.2017. [2]. Cully M. Anticancer drugs: Exploiting a weakness in colorectal cancers. Nat Rev Drug Discov. 2016 Nov 29;15(12):820-821.
CoA	CoA of TASIN-1 Hydrochloride

Smiles:	CC1CCN(C2CCN(S(=O)(C3=CC=C(OC)C=C3)=O)CC2)CC1.[H]Cl


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