TAPI-1

(S,S)-TAPI-1 is an isomer of TAPI-1. TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor.


Cat. No.: EX-A1664	Purity: 95%+

	Chemical structure of TAPI-1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	485	In-stock
10mg	700	In-stock
100mg	1650	In-stock
200mg	2350	In-stock
1g	3800	In-stock
5g	13800	In-stock

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Synonyms	(S,S)-TAPI-1
CAS No.	171235-71-5
Purity	95%+
Formula	C26H37N5O5
Mol Weight	499.6025
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Slack, B E et al. “Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme.” The Biochemical journal vol. 357,Pt 3 (2001): 787-94. [2]. Bae EH, et al. Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells. Korean J Physiol Pharmacol. 2 [3]. Moss ML, et al. Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation. Mediators Inflamm. 2017;2017:9673537.
CoA	CoA of TAPI-1

Smiles:	CC(C)CC(CC(=O)NO)C(=O)N[C@@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](C)C(=O)NCCN


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