Tanomastat

Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models.


Cat. No.: EX-A7633	Purity: >98%

	Chemical structure of Tanomastat

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
5mg	680	Inquire
1g	2800	6-8 weeks

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Synonyms	BAY 12-9566
CAS No.	179545-77-8
Purity	>98%
Formula	C23H19ClO3S
Mol Weight	410.913
Color	White to off-white
State	solid powder
Solubility	DMSO : 25 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Leung D, et al. Protease inhibitors: current status and future prospects. J Med Chem. 2000 Feb 10;43(3):305-41. [2]. Gatto C, et al. BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activity. Clin Cancer Res. 1999 Nov;5(11):3603-7. [3]. Nozaki S, et al. Activity of biphenyl matrix metalloproteinase inhibitor BAY 12-9566 in a human breast cancerorthotopic model. Clin Exp Metastasis. 2003;20(5):407-12.
CoA	CoA of Tanomastat


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