Taniborbactam dihydrochloride

Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria.


Cat. No.: EX-A5157A	Purity: >98%

	Chemical structure of Taniborbactam dihydrochloride

For research only, Do not use for Human!

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Synonyms	VNRX-5133 dihydrochloride
CAS No.	2244235-49-0
Purity	>98%
Formula	C19H30BCl2N3O5
Mol Weight	462.176
Color	Off-white to light yellow
State	Solid
Solubility	DMSO : 200 mg/mL H2O : 33.33 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, protect from light, stored under nitrogen; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Krajnc A, et al. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. J Med Chem. 2019 Sep 26;62(18):8544-8556. [2]. Liu B ,et al. Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2019 Dec 16.
CoA	CoA of Taniborbactam dihydrochloride

Smiles:	B1([C@H](CC2=C(O1)C(=CC=C2)C(=O)O)NC(=O)CC3CCC(CC3)NCCN)O.Cl.Cl


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