Talotrexin

Talotrexin (PT523), an analog of Aminopterin, is a nonpolyglutamatable classic antifolate. Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitumor activity by targeting DHFR to inhibit tumor growth.


Cat. No.: EX-A13882	Purity: >98%

	Chemical structure of Talotrexin

For research only, Do not use for Human!

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Synonyms	PT523
CAS No.	113857-87-7
Purity	>98%
Formula	C27H27N9O6
Mol Weight	573.56
Color	Light yellow to yellow
State	Solid
Solubility	DMSO : 125 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. O'Connor C, et al. Folate transporter dynamics and therapy with classic and tumor-targeted antifolates. Sci Rep. 2021 Mar 18;11(1):6389. [2]. Choy G S, et al. Combination talotrexin (PT-523) with paclitaxel in A549 non-small cell lung cancer (NSCLC) athymic nude mice xenografts[J]. Cancer Research, 2007, 67(1_Annual_Meeting).
CoA	CoA of Talotrexin

Smiles:	NC1=NC(N)=NC2=C1N=C(CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCCNC(C4=C(C=CC=C4)C(O)=O)=O)=O)C=N2


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