TAK-418

TAK-418 is a selective, orally active LSD1 (KDM1A) enzyme inhibitor with an IC50 of 2.9 nM. TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models.


Cat. No.: EX-A8805	Purity: >98%

	Chemical structure of TAK-418

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	900	In-stock
250mg	1500	In-stock
500mg	2400	In-stock
1g	3800	In-stock
2g	get quote	In-stock
5g	get quote	In-stock

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CAS No.	1818252-53-7
Purity	>98%
Formula	C17H25ClN2O2S
Mol Weight	356.911
Color	White to yellow
State	Solid-Liquid Mixture
Solubility	Soluble in DMSO/H2O
Shelf Life	>2 years if stored properly
Storage	-20℃, sealed storage, away from moisture and light
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Baba R, et al. LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models. Sci Adv. 2021;7(11):eaba1187. Published 2021 Mar 12. [2]. Zhang L, et al. Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome. Mol Ther Methods Clin Dev. 2021;20:779-791. Published 2021 Feb 18
CoA	CoA of TAK-418


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