background


Product Information:

TAK-020

TAK-020 is a highly selective covalent BTK inhibitor that inhibits both B cell receptor and fragment crystallizable receptor signaling

Cat. No.: EX-A5379    Purity: >98%
Chemical
Chemical structure of TAK-020


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
10mg506in_stock
25mg933in_stock
50mg1437in_stock
100mg2204in_stock
250mg3345in_stock


CAS No.1627603-21-7
Purity>98%
FormulaC18H17N5O3
Mol Weight351.3593
ColorWhite to off-white
Statesolid powder
SolubilitySoluble in DMSO 20.83 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Sabat M, Dougan DR, Knight B, Lawson JD, Scorah N, Smith CR, Taylor ER, Vu P, Wyrick C, Wang H, Balakrishna D, Hixon M, Madakamutil L, McConn D. Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design. J Med Chem. 2021 Sep 9;64(17):12893-12902. doi: 10.1021/acs.jmedchem.1c01026. Epub 2021 Aug 27. PMID: 34448571.

[2]. Esfandiari E, Chen M, Smithson G, Blair D, Faessel H, Wagner J, Mclean L, Fedyk ER. A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single-Dose and Multiple-Rising-Dose Study of the BTK Inhibitor TAK-020 in Healthy Subjects. Clin Transl Sci. 2021 May;14(3):820-828. doi: 10.1111/cts.12871. Epub 2021 Mar 2. PMID: 33650758; PMCID: PMC8212709.
CoACoA of TAK-020
Smiles:O=C1NNC(C2=CC3=C(C(O[C@@H]4CN(C(C=C)=O)CC4)=N2)C=CC=C3)=N1

KEYWORDS: buy TAK-020 | TAK-020 supplier | purchase | cost | manufacturer | order | distributor | buy 1627603-21-7 | 1627603-21-7 supplier