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Product Information:

TA-8995

TA-8995 (Obicetrapib) is a selective inhibitor of cholesteryl ester transfer protein.

Cat. No.: EX-A6112    Purity: >98%
Chemical
Chemical structure of TA-8995


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg478in_stock
100mg754in_stock
250mg1555in_stock
500mg2495in_stock
1g3983in_stock
2g6378in_stock


SynonymsObicetrapib
Synonyms 2AMG-899
CAS No.866399-87-3
Purity>98%
FormulaC32H31F9N4O5
Mol Weight722.598
Colorwhite to light yellow
Statesolid powder
SolubilitySoluble in DMSO ? 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4℃ 2 years ; -20℃ 3 years ; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Filippatos TD, et al. Cholesteryl ester transfer protein inhibitors: challenges and perspectives. Expert Rev Cardiovasc Ther. 2016 Aug;14(8):953-62.

[2]. Amgen bulks out cardio package. Nat Biotechnol. 2015 Nov;33(11):1118. doi: 10.1038/nbt1115-1118a.

[3]. Mearns BM. Dyslipidaemia: Promising results for TA-8995 in TULIP. Nat Rev Cardiol. 2015 Aug;12(8):443.

[4]. Hovingh GK, et al. Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet. 2015 Aug 1;386(9992):452-60.

CoACoA of TA-8995
Smiles:FC(F)(F)C1=CC(C(F)(F)F)=CC(CN(C2=NC=C(OCCCC(O)=O)C=N2)[C@@H]3C4=CC(C(F)(F)F)=CC=C4N([C@@H](C3)CC)C(OCC)=O)=C1

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