Synucleozid hydrochloride

Synucleozid hydrochloride (NSC 377363 hydrochloride) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein. Synucleozid selectively targets the α-synuclein mRNA 5' UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson's disease.


Cat. No.: EX-A8538A	Purity: >98%

	Chemical structure of Synucleozid hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	800	In-stock
50mg	1250	In-stock
100mg	1850	In-stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


Synonyms	NSC 377363 hydrochloride
CAS No.	2741856-68-6
Purity	>98%
Formula	C22H21ClN6
Mol Weight	404.895
Color	Light yellow to yellow
State	solid powder
Solubility	DMSO : 125 mg/mL H2O : 2 mg/mL
Shelf Life	>1 years if stored properly
Storage	4°C, sealed storage, away from moisture
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.
CoA	CoA of Synucleozid hydrochloride

Smiles:	N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(NC4=CC=C(C(N)=N)C=C4)C=C3)N2)N.Cl


		Search