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Product Information:

SY-5102

SY-5102 is a potent, selective, and orally active cyclin-dependent kinase (CDK7) inhibitor with a Kd value of 0.03 nM. SY-5102 occupies the ATP-binding pocket of CDK7 via non-covalent binding to inhibit CDK7 activity, and downregulates its phosphorylation of cyclin CDK and RNA polymerase II. SY-5102 inhibits cancer cell proliferation, and induces tumor growth inhibition and regression. SY-5102 can be used in research related to triple-negative breast cancer.

Cat. No.: EX-A6501    Purity: >98%
Chemical
Chemical structure of SY-5102


For research only, Do not use for Human!

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CAS No.2365230-48-2
Purity>98%
FormulaC22H22F3N7O
Mol Weight457.4516
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Marineau JJ, et al. Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7. Journal of medicinal chemistry. 2022 Jan 27;65(2):1458-1480.

CoACoA of SY-5102

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