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Product Information:

SUCNR1-IN-1

SUCNR1-IN-1 (Compound 20) is a SUCNR1 inhibitor (IC50: 88 nM for hSUCNR1). SUCNR1-IN-1 can be used for research of rheumatoid arthritis, liver fibrosis, or obesity.

Cat. No.: EX-A8763    Purity: >98%
Chemical
Chemical structure of SUCNR1-IN-1


For research only, Do not use for Human!

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CAS No.2711753-52-3
Purity>98%
FormulaC26H22ClF3N2O4
Mol Weight518.912
ColorWhite to off-white
Statesolid powder
SolubilityDMSO : 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder   -20°C, 3 years , 4°C, 2 years ; In solvent   -20°C, 1 month
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Velcicky J, et al. Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure. J Med Chem. 2020 Sep 10;63(17):9856-9875.

CoACoA of SUCNR1-IN-1
Smiles:FC1=CC(Cl)=C(O[C@@H]2CCCNC2)C=C1C3=C(C(C(NC4=C(C=C(C=C4)F)CC(O)=O)=O)=CC=C3)F

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