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Product Information:

STF-3600

STF-3600 is a LRRK2 G2019S inhibitor with an IC50 of 0.9 nM against the human target. It has oral activity and can cross the blood-brain barrier. STF-3600 selectively inhibits kinase activity, including autophosphorylation at Ser935 and Ser1292, as well as phosphorylation of the endogenous substrate Rab10 at Thr73. STF-3600 inhibits vacuolization of type II pulmonary epithelial cells in wild-type/heterozygous mice, while it induces this vacuolization phenotype in homozygous mice. STF-3600 can be used in Parkinson's disease research .

Cat. No.: EX-A17572    Purity:
Chemical
Chemical structure of STF-3600


For research only, Do not use for Human!

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CAS No.2765654-79-1
FormulaC24H21N5
Mol Weight379.457
 
 
CoACoA of STF-3600
Smiles:CC1=CC(C2=NNC3=CC=C(C=C23)N[C@@H]4C5=CC=C(C#N)C=C5CCC4)=CC=N1

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