SST0116CL1

SST0116CL1 is a HSP90 inhibitor (IC50: 0.21 μM). SST0116CL1 binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 induces degradation of Her2 in BT-474 cell (IC50: 0.2 μM). SST0116CL1 has antiproliferative activity and inhibits tumor growth. SST0116CL1 can be used for the study of leukemia, gastric and ovarian carcinoma.


Cat. No.: EX-A13201	Purity: >98%

	Chemical structure of SST0116CL1

For research only, Do not use for Human!

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CAS No.	1799802-29-1
Purity	>98%
Formula	C22H31ClN4O6
Mol Weight	482.958
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Vesci L, et al. Preclinical antitumor activity of SST0116CL1: a novel heat shock protein 90 inhibitor. Int J Oncol. 2014 Oct;45(4):1421-9.
CoA	CoA of SST0116CL1

Smiles:	Cl.O=C(NCC)C1=NOC(C=2C=C(C(O)=CC2O)C(C)C)=C1NC(=O)CCN3CCOCC3


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