SRI-42127

SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation.


Cat. No.: EX-A8474	Purity: >98%

	Chemical structure of SRI-42127

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
100mg	900	In-stock
200mg	1350	In-stock

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CAS No.	2727872-68-4
Purity	>98%
Formula	C19H20N6O
Mol Weight	348.4017
Color	White to light yellow
State	solid powder
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Chellappan R, et al. SRI-42127, a novel small molecule inhibitor of the RNA regulator HuR, potently attenuates glial activation in a model of lipopolysaccharide-induced neuroinflammation. Glia. 2022 Jan;70(1):155-172.
CoA	CoA of SRI-42127

Smiles:	CN(C1CCOCC1)C2=NN3C(C=C2)=NC=C3C4=CC5=C(C=C4)C=NN5


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