SPOP-IN-1

SPOP-i-6lc is a selective SPOP E3 ubiquitin ligase inhibitor (IC50 = 2.1 μM and 3.5 μM, in A498 and OS-RC-2 cell lines, respectively). In vitro, SPOP-i-6lc suppresses viability and proliferation of A498 and OS-RC-2 kidney cancer cell lines. SPOP-i-6lc leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK in clear-cell renal cell carcinoma (ccRCC) cell lines.


Cat. No.: EX-A8087	Purity: >98%

	Chemical structure of SPOP-IN-1

For research only, Do not use for Human!

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Synonyms	SPOP-i-6lc
CAS No.	2136270-56-7
Purity	>98%
Formula	C26H31N7O2S
Mol Weight	505.635
Color	Light yellow to yellow
State	solid powder
Solubility	DMSO : 5 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Dong Z, Wang Z, Guo ZQ, Gong S, Zhang T, Liu J, Luo C, Jiang H, Yang CG. Structure-Activity Relationship of SPOP Inhibitors against Kidney Cancer. J Med Chem. 2020 May 14;63(9):4849-4866. doi: 10.1021/acs.jmedchem.0c00161. Epub 2020 Apr 27. Erratum in: J Med Chem. 2021 Jan 14;64(1):905. PMID: 32297747.
CoA	CoA of SPOP-IN-1

Smiles:	CN1CCN(CC1)CCNC(C2=CC3=C(N(C2=N)CCC4=CC=CS4)N=C5N(C3=O)C=CC=C5C)=O


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