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Product Information:

SOS1 activator 2

SOS1 activator 2 (Compound 65) is a benzimidazole derivative and a SOS1 activator. SOS1 activator 2 has a high binding affinity for SOS1 with a Kd of 9 nM. SOS1 activator 2 can regulate the Ras-ERK signaling pathway, which can be used in the study of cancer .

Cat. No.: EX-A12232    Purity: >98%
Chemical
Chemical structure of SOS1 activator 2


For research only, Do not use for Human!

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CAS No.2245237-54-9
Purity>98%
FormulaC26H28ClFN6
Mol Weight478.992
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Hodges TR, et al. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61(19):8875-8894.

CoACoA of SOS1 activator 2

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