SNJ-1945

SNJ-1945 is an orally active Calpain inhibitor that can cross the blood-brain barrier. SNJ-1945 protects rat hearts against cardiac arrest-reperfusion injury by inhibiting the hydrolysis of α-fodrin. SNJ-1945 inhibits VEGF-induced angiogenesis in retinal endothelial cells. SNJ-1945 also protects SH-SY5Y cells from damage induced by MPP+ and Rotenone. SNJ-1945 exhibits anti-inflammatory and neuroprotective activities in a mouse model of multiple sclerosis. SNJ-1945 can be used for the research of cardiovascular, nervous system and inflammatory diseases .


Cat. No.: EX-A9513	Purity: >98%

	Chemical structure of SNJ-1945

For research only, Do not use for Human!

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CAS No.	854402-59-8
Purity	>98%
Formula	C25H37N3O7
Mol Weight	491.5772
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yoshikawa Y, et al. Cardioprotective effects of a novel calpain inhibitor SNJ-1945 for reperfusion injury after cardioplegic cardiac arrest. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H643-51. [2]. Ma H, et al. Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells. J Ocul Pharmacol Ther. 2009 Oct;25(5):409-14. [3]. Knaryan VH, et al. SNJ-1945, a calpain inhibitor, protects SH-SY5Y cells against MPP(+) and rotenone. J Neurochem. 2014 Jul;130(2):280-90. [4]. Trager N, et al. Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis. J Neurochem. 2014 Jul;130(2):268-79.
CoA	CoA of SNJ-1945

Smiles:	O=C(OCCOCCOC)N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(C(NC2CC2)=O)=O)=O)CC(C)C


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