SNIPER(BRD)-1

SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively .


Cat. No.: EX-A8620	Purity: >98%

	Chemical structure of SNIPER(BRD)-1

For research only, Do not use for Human!

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CAS No.	2095244-54-3
Purity	>98%
Formula	C53H66ClN9O8S2
Mol Weight	1056.73
Color	Off-white to light yellow
State	solid powder
Solubility	DMSO : 66.67 mg/mL
Shelf Life	>3 years if stored properly
Storage	-20°C, stored under nitrogen
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER). Chemical & pharmaceutical bulletin. 2019 Mar 01;67(3):203-209.
CoA	CoA of SNIPER(BRD)-1

Smiles:	O=C(C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1)NCCOCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@@H](NC([C@H](C)NC)=O)C8CCCCC8)=O)CCC7)=N6)=O)=CC=C5


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