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Product Information:

SMS2-IN-1

SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM).

Cat. No.: EX-A5038    Purity: >98%
Chemical
Chemical structure of SMS2-IN-1


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
25mg895In-stock
50mg1450In-stock
100mg2550In-stock


Synonyms1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
CAS No.2098890-15-2
Purity>98%
FormulaC34H37F6N3O5
Mol Weight681.6651
ColorWhite to off-white
Statesolid powder
SolubilitySoluble in DMSO 27.78 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Adachi R, et al. Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors. Eur J Med Chem. 2017 Aug 18;136:283-293.
CoACoA of SMS2-IN-1
Smiles:O=C1C(C(N(CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C)=O)=C(OCCCC3CCN(C(OC4(CC4)C)=O)CC3)C5=CC=CC=C5N1C

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