SMD-3040

SMD-3040 is a potent and selective of SMARCA2 PROTAC degrader (DC50: 12 nM). SMD-3040 demonstrates excellent degradation selectivity for SMARCA2 protein over SMARCA4 protein.SMD-3040 achieves strong tumor growth inhibition in xenograft models[1].


Cat. No.: EX-A10415	Purity: >98%

	Chemical structure of SMD-3040

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	895	In-stock
25mg	1686	In-stock
50mg	2650	In-stock
100mg	3950	In-stock
250mg	get quote	In-stock
500mg	get quote	In-stock

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CAS No.	3033109-92-8
Purity	>98%
Formula	C52H66N10O5S
Mol Weight	943.209
Color	off-white to white
State	powder
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 year; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yang L, et.al. Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity. J Med Chem. 2023 Jul 31.
CoA	CoA of SMD-3040

Smiles:	O=C(N[C@H](C(N1[C@H](C(N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)C[C@@H](O)C1)=O)C(C)(C)C)[C@H]4CC[C@H](CN5CC6(CCC(N7N=CC(C8=C(N)N=NC(C9=C(O)C=CC=C9)=C8)=C7)CC6)C5)CC4


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