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Product Information:

SKF 89976A hydrochloride

SKF89976A hydrochloride is a selective GABA transporter (GAT-1) inhibitor with IC50s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.

Cat. No.: EX-A6069    Purity: >98%
Chemical
Chemical structure of SKF 89976A hydrochloride


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg450In-stock
100mg550In-stock
200mg750In-stock
500mg1150In-stock
1g1700In-stock
5g4800In-stock


CAS No.85375-15-1
Purity>98%
FormulaC22H26ClNO2
Mol Weight371.9
ColorLight yellow to khaki
Statesolid powder
SolubilitySoluble in DMSO 100 mg/mL H2O 20 mg/mL
Shelf Life>2 years if stored properly
StoragePowder 4°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Jinzenji A, et al. Antiallodynic action of 1-(3-(9H-Carbazol-9-yl)-1-propyl)-4-(2-methyoxyphenyl)-4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor. J Pharmacol Sci. 2014;125(2):217-26.

[2]. Kreitzer MA, et al. Glutamate modulation of GABA transport in retinal horizontal cells of the skate. J Physiol. 2003 Feb 1;546(Pt 3):717-31.

[3]. Barakat L, et al. GAT-1 and reversible GABA transport in Bergmann glia in slices. J Neurophysiol. 2002 Sep;88(3):1407-19.

CoACoA of SKF 89976A hydrochloride

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