SK2188

SK2188 (JB325) is a selective AURKA PROTAC degrader with a DC50 of 3.9 nM. SK2188 recruits CRBN E3 ubiquitin ligase to target and degrade AURKA, abrogating both its catalytic and non-kinase functions, which leads to the destabilization and degradation of the oncogenic protein MYCN, ultimately inducing replication stress, DNA damage and apoptosis. SK2188 is applicable to research related to neuroblastoma .


Cat. No.: EX-A17542	Purity: >98%

	Chemical structure of SK2188

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	383	in_stock
25mg	755	in_stock
50mg	1198	in_stock
100mg	1884	in_stock
250mg	3816	in_stock
500mg	6084	in_stock

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CAS No.	3038446-94-2
Purity	>98%
Formula	C43H46ClFN6O10S
Mol Weight	893.376
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Rishfi M, et al. Targeted AURKA degradation: Towards new therapeutic agents for neuroblastoma. European journal of medicinal chemistry. 2023 Feb 05;247:115033.
CoA	CoA of SK2188

Smiles:	O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCCOCCOCCOCCNC([C@@]4(CC[C@H](CC4)OC5=C(C(Cl)=CC=C5)F)CC6=CC=CC(NC7=NC=CS7)=N6)=O)=C3C1=O


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