SK-575

SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1, with an IC50 of 2.30 nM. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations.


Cat. No.: EX-A7398	Purity: >98%

	Chemical structure of SK-575

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	1085	In-stock
100mg	1585	In-stock
200mg	2285	In-stock
500mg	3085	In-stock

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CAS No.	2523016-96-6
Purity	>98%
Formula	C47H53FN8O8
Mol Weight	876.9709
Color	Light yellow to yellow
State	solid powder
Solubility	DMSO : 80 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Cao C, et al. Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. J Med Chem. 2020 Oct 8;63(19):11012-11033.
CoA	CoA of SK-575


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