Inhibitor Specialist 
Product Information:
| Cat. No.: EX-A1151 | Purity: >98% |
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| Chemical structure of SIS3 |
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| Synonyms | (E)-SIS3 |
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| Synonyms 2 | SIS3 hydrobromide |
| CAS No. | 521984-48-5 |
| Purity | >98% |
| Formula | C28H28ClN3O3 |
| Mol Weight | 489.993 |
| Color | white to off-white |
| State | powder |
| Solubility | DMSO >20mg/mL |
| Shelf Life | >2 years if stored properly |
| Storage | Powder -20℃ 2 years; In solvent -20℃ 1 month; |
| Shipping | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Reference: | [1]. Boudreau HE et al. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells. Br J Cancer. 2014 May 13;110(10):2569-82.
[2]. Jinnin M et al. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607. |
| CoA | CoA of SIS3 |
| Smiles: | Cl.COC1=CC2=C(CN(CC2)C(=O)\C=C\C2=C(N(C)C3=NC=CC=C23)C2=CC=CC=C2)C=C1OC |
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