SIRT4-IN-1

SIRT4-IN-1 is a selective and potent Sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM for hSirt4. SIRT4-IN-1 also inhibits hSirt1, hSirt2, hSirt3, hSirt4 and hSirt6. SIRT4-IN-1 competes with acyl peptide substrate for Sirt4's acyl binding site, and is noncompetitive with NAD +. SIRT4-IN-1 increases glutamate dehydrogenase (GDH) activity and rescues pyruvate dehydrogenase (PDH) activity. SIRT4-IN-1 inhibits adipocyte differentiation and suppresses Sirt4 overexpression-induced increased differentiation. SIRT4-IN-1 can be used for the researches of cancer and metabolic disease .


Cat. No.: EX-A16869	Purity: >98%

	Chemical structure of SIRT4-IN-1

For research only, Do not use for Human!

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CAS No.	3030697-87-8
Purity	>98%
Formula	C19H13N5O6S3
Mol Weight	503.531
Color	White to yellow
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, protect from light; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Pannek M, et al. Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity. J Med Chem. 2024;67(3):1843-1860.
CoA	CoA of SIRT4-IN-1

Smiles:	O=C1C2=C(N=C(N1)SCC(NC3=NC=C(S3)S(C4=CC=C(C=C4)[N+]([O-])=O)(=O)=O)=O)C=CC=C2


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