SIK-IN-4

PF-07899895 (Compound 34) is a SIK inhibitor, with IC50 values of 1.2 nM, 0.9 nM, and 1.8 nM against SIK1, SIK2, and SIK3, respectively. PF-07899895 modulates the anti-inflammatory cytokine IL-10 in immune cells. PF-07899895 is applicable to research related to inflammatory diseases.


Cat. No.: EX-A13243	Purity: >98%

	Chemical structure of SIK-IN-4

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	350	In-stock
25mg	680	In-stock
50mg	1230	In-stock
100mg	2030	In-stock

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CAS No.	3033846-10-2
Purity	>98%
Formula	C23H23N5OS
Mol Weight	417.527
Color	Light yellow to yellow
State	Solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Andrea Nicole BOOTSMA, et al. Heterocyclic sik inhibitors. Patent WO2024062360.
CoA	CoA of SIK-IN-4

Smiles:	N#CC1=CC=CC2=NC=C(C=3C=C(OCC4(N)CCCCC4)C(C#N)=C(SC)C3)N12


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