SIAIS164018

SIAIS164018 is a PROTAC-based ALK and EGFR degrader, which is designed from Brigatinib, with IC50 value of 2.5 nM and 6.6 nM for ALK and ALK G1202R, respectively. SIAIS164018 strongly inhibits cancer cells migration and invasion, causes G1 cell cycle arrest and induces apoptosis. SIAIS164018 exhibits better property than Brigatinib.


Cat. No.: EX-A7162	Purity: >98%

	Chemical structure of SIAIS164018

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	1085	Inquire
100mg	2800	Inquire
250mg	3800	Inquire
1g	5960	Inquire

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CAS No.	2353492-68-7
Purity	>98%
Formula	C43H48ClN10O7P
Mol Weight	883.331
State	solid powder
Solubility	Soluble in DMSO 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ren C, et al. Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile. J Med Chem. 2021 Jul 8;64(13):9152-9165.
CoA	CoA of SIAIS164018


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