SI-109

SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36.


Cat. No.: EX-A9476	Purity: >98%

	Chemical structure of SI-109

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	4800	Inquire
250mg	7800	Inquire
500mg	12800	Inquire
1g	get quote	Inquire

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CAS No.	2429877-30-3
Purity	>98%
Formula	C40H44F2N7O9P
Mol Weight	835.7894
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Storage	-80°C, stored under nitrogen
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17.
CoA	CoA of SI-109

Smiles:	O=C([C@@H](NC([C@@H]1CC[C@H](CCN(C(C)=O)C[C@@H]2NC(C3=CC(C=C(C(F)(P(O)(O)=O)F)C=C4)=C4N3)=O)N1C2=O)=O)CCC(N)=O)NC(C5=CC=CC=C5)C6=CC=CC=C6


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