SHP2-IN-9

SHP2-IN-9 is a specific SHP2 inhibitor (IC50 =1.174 μM) with enhanced blood–brain barrier penetration. SHP2-IN-9 shows 85-fold more selective for SHP2 than SHP1. SHP2-IN-9 inhibits SHP2-mediated cell signal transduction and cancer cell proliferation, and inhibits the growth of cervix cancer tumors and glioblastoma growth in vivo.


Cat. No.: EX-A8690	Purity: >98%

	Chemical structure of SHP2-IN-9

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	685	In-stock
250mg	1100	In-stock
500mg	1650	In-stock
1g	2350	In-stock

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CAS No.	2987135-92-0
Purity	>98%
Formula	C20H20FN3O2S
Mol Weight	385.455
Color	white to off-white
State	solid powder
Solubility	DMSO: 33.33 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ma Y, et al. Structure-based discovery of a specific SHP2 inhibitor with enhanced blood-brain barrier penetration from PubChem database. Bioorg Chem. 2022;121:105648.
CoA	CoA of SHP2-IN-9

Smiles:	O=C(NCC1=CC=C(C=C1)F)CN2C=NC3=C(C4=C(S3)CCCCC4)C2=O


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