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Product Information:

SHP099 hydrochloride

SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM.

Cat. No.: EX-A2413    Purity: >98%
Chemical
Chemical structure of SHP099 hydrochloride


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg580In-stock
500mg880In-stock
1g1350In-stock
2g2300In-stock


CAS No.1801747-11-4
Purity>98%
FormulaC16H20Cl3N5
Mol Weight388.722
Statesolid powder
SolubilityDMSO 4mg/mL (Need ultrasonic and warming)
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59(17):7773-82.

[2]. Chen YN, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016 Jul 7;535(7610):148-52.

[3]. Carmine Fedele, et al. SHP2 Inhibition Abrogates MEK inhibitor Resistance in Multiple Cancer Models. bioRxiv. April 25, 2018.
CoACoA of SHP099 hydrochloride
Smiles:Cl.CC1(N)CCN(CC1)C1=CN=C(C(N)=N1)C1=CC=CC(Cl)=C1Cl

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