SGC-iMLLT

SGC-iMLLT is a first-in-class chemical probe and a potent, selective inhibitor of MLLT1/3-histone interactions with an IC50 of 0.26 μM. SGC-iMLLT shows high binding activity towards MLLT1 YEATS domain (YD) and MLLT3 YD (AF9/YEATS3) with Kds of 0.129 and 0.077 μM, respectively.


Cat. No.: EX-A5088	Purity: >98%

	Chemical structure of SGC-iMLLT

For research only, Do not use for Human!

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250mg	get quote

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CAS No.	2255338-25-9
Purity	>98%
Formula	C22H24N6O
Mol Weight	388.4656
Color	Light yellow to yellow
State	solid powder
Solubility	Soluble in DMSO 83.33 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Moustakim M, et al. Discovery of an MLLT1/3 YEATS Domain Chemical Probe. Angew Chem Int Ed Engl. 2018 Dec 10;57(50):16302-16307.
CoA	CoA of SGC-iMLLT

Smiles:	CN1N=CC2=CC(C(NC3=CC=C(NC(CN4[C@@H](C)CCC4)=N5)C5=C3)=O)=CC=C21


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