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Product Information:

SG3249

SG3249 (Tesirine, PBD 3249) is made by Pyrrolobenzodiazepine (PBDs) conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker.

Cat. No.: EX-A6241    Purity: >98%
Chemical
Chemical structure of SG3249


For research only, Do not use for Human!

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SynonymsTesirine
Synonyms 2PBD 3249
CAS No.1595275-62-9
Purity>98%
FormulaC75H101N9O23
Mol Weight1496.6509
ColorWhite to light yellow
Statesolid powder
SolubilityDMSO : 200 mg/mL (133.63 mM; Need ultrasonic)
Shelf Life>2 years if stored properly
StoragePowder -20℃, protect from light, stored under nitrogen, 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Tiberghien AC, et al. Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload. ACS Med Chem Lett. 2016;7(11):983-987. Published 2016 May 24.

[2]. Hartley JA, et al. Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine. Sci Rep. 2018;8(1):10479. Published 2018 Jul 11.

CoACoA of SG3249

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