SG3199

SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249).


Cat. No.: EX-A6229	Purity: >98%

	Chemical structure of SG3199

For research only, Do not use for Human!

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Synonyms	PBD 1
Synonyms 2	PBD1
CAS No.	1595275-71-0
Purity	>98%
Formula	C33H36N4O6
Mol Weight	584.6621
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 130 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20°C, protect from light, stored under nitrogen; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. John A Hartley, et al. Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine. Sci Rep. 2018 Jul 11;8(1):10479. [2]. Francesca Zammarchi, et al. ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies. Blood. 2018 Mar 8;131(10):1094-1105.
CoA	CoA of SG3199


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