Sevabertinib

Sevabertinib (BAY 2927088) is an orally active and reversible dual EGFR-HER2 inhibitor (IC50 <0.5 nM for wild-type HER2, HER2 A775insYVMA, wild-type EGFR, and EGFR D770_N771insSVD). Sevabertinib has anticancer activity against lung cancer.


Cat. No.: EX-A12844	Purity: >98%

	Chemical structure of Sevabertinib

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	480	In-stock
250mg	950	In-stock
500mg	1520	In-stock
1g	2430	In-stock
2g	3900	In-stock
3g	4670	In-stock

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Synonyms	BAY-2927088
CAS No.	2521285-05-0
Purity	>98%
Formula	C24H25ClN4O5
Mol Weight	484.932
Color	Light yellow to yellow
State	Solid
Solubility	DMSO : 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 38, No. 2, 2024. [2]. Siegel F, et al. Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer. Cancer Discov. 2025 Oct 15.
CoA	CoA of Sevabertinib

Smiles:	O=C(NCC1)C2=C1NC(C3=CC=NC=C3OC[C@@H]4COCCO4)=C2NC5=C(C(Cl)=CC=C5)OC


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