Setmelanotide

Setmelanotide (RM-493; BIM-22493; IRC-022493) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.


Cat. No.: EX-A5542	Purity: >98%

	Chemical structure of Setmelanotide

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	450	In-stock
100mg	600	In-stock
250mg	1100	In-stock
500mg	1450	In-stock
1g	1885	In-stock
5g	get quote	In-stock

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Synonyms	RM 493
Synonyms 2	Imcivree
CAS No.	920014-72-8
Purity	>98%
Formula	C49H68N18O9S2
Mol Weight	1117.309
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 100 mg/mL H2O 58.33 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -80℃ 2 years, -20°C 1 year, Sealed storage, away from moisture; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Chen, Kong Y et al. RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals. The Journal of clinical endocrinology and metabolism vol. 100,4 (2015): 1639-45. [2]. Clemmensen, Christoffer et al. Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice. EMBO molecular medicine vol. 7,3 (2015): 288-98. [3]. Kievit, Paul et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes vol. 62,2 (2013): 490-7.
CoA	CoA of Setmelanotide


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