Seneciphylline

Seneciphylline is an orally effective hepatotoxic inducer. Seneciphylline is metabolized by CYP450 enzymes into active intermediates, which covalently bind to intracellular biomacromolecules such as proteins and DNA to form adducts, which in turn trigger a series of toxic reactions, such as inducing cell apoptosis and damaging mitochondrial function. Seneciphylline can be used in hepatotoxicity research[1][2].


Cat. No.: EX-A11101	Purity: >98%

	Chemical structure of Seneciphylline

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	625	In-stock
250mg	1025	In-stock
500mg	1525	In-stock
1g	2125	In-stock

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CAS No.	480-81-9
Purity	>98%
Formula	C18H23NO5
Mol Weight	333.3789
Color	White to off-white
State	Solid
Solubility	DMSO : 7.69 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, protect from light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kakrani HK, et al. Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. J Ethnopharmacol. 1984 Dec;12 (3) :271-8. [2]. Wang W, et al. Seneciphylline, a main pyrrolizidine alkaloid in Gynura japonica, induces hepatotoxicity in mice and primary hepatocytes via activating mitochondria-mediated apoptosis. J Appl Toxicol. 2020 Nov;40 (11) :1534-1544.
CoA	CoA of Seneciphylline

Smiles:	O=C(O[C@]1([H])CCN2[C@]1([H])C(COC([C@](C)(O)C(C/3)=C)=O)=CC2)C3=C/C


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